390 Geographical and environmental factors associated with melanoma incidence in Canada

Background: We sought to examine the relationship between environmental factors and Canada's distribution of melanoma incidence 1992 2010. Methods: Data was obtained from Canadian Cancer Registry, Vital Statistics, Urban Environmental Health Research Consortium. Crude rates were for forward sortation areas (FSAs). Enviromental variables included: normalized difference vegetation index (NDVI) as a proxy green space, precipitation, yearly temperature, number weather events 1992-2010. exposures modeled tertiles via two-level random-effect generalized linear model evaluate dose-response relationship. Results: Across Canada, average annual temperature increased significantly over time (p < 0.0001). Other significant increases absolute amount well heat rain. Greatest observed in Newfoundland, PEI Manitoba. A positive rate confirmed (Beta: 6.23, 95%CI: 5.2, 9.93). With each increase NDVI, odds doubled high-risk FSAs compared those with low-risk (OR: 2.72, 2.49, 2.97; & OR = 4.31, 3.91, 4.76; 2 3 respectively). Discussion: Consistent strong relationships changes enviromental this study. High ambient leads more outdoors, less protective clothing, greater sunburns. The presence parks an abundance foliage may encourage public spend outdoors increasing UVR exposure. Public health advice be improved by taking account both space accesibility their implications behaviour.